Research Projects


As part of the research program, each partner site has planned a series of research projects that each contribute to different domains, clusters and lighthouse projects.

BE 1: Understanding individual risk and resilience factors for mental and physical health across the lifespan (Matthias Rose, Christoph U. Correll)

BE 2: Targeted interventions using an adaptive platform (Christian Otte, Christine Knaevelsrud)

BE 3: Considering the social determinants of mental health risks and outcomes to optimize interventions (Andreas Heinz, Michael Rapp)

BE 4: Research priorities from the perspective of users/patients/peers and relatives and establishment of a panel of experts by experience (Isabel Dziobek, Silke Lipinski)

BE 5: Promotion of national and international cooperation (Andreas Heinz, Rüdiger Hannig)

BO1: Longitudinal investigation of the relationship between aversive childhood experiences, stress processing and learning and memory processes (Sabine Seehagen)

BO2: Development of a longitudinal research framework to describe trajectories and mechanisms of mental health and disorder across the lifespan (Jürgen Margraf)

BO3: Investigation of bidirectional transgenerational effects in the transmission of mental disorders and development of transgenerational psychotherapy approaches (Hanna Christiansen)

BO4: Cross-sector inventory of psychosocial counseling services (Freia de Bock)

BO5: Promoting the mental health of children, adolescents, and their families in an urban context with a special focus on neighborhoods with a low socio-economic background (Silvia Schneider)

BO6: Investigation of the lasting effect and the mechanisms responsible for the long-term effectiveness of psychotherapy (Silvia Schneider, Jürgen Margraf)

BO7: Strategies to protect the integrity and privacy of primary patient data while adhering to open science principles for research data (Jörg Schwenk)

JE1: The circuit basis of behavioral (mal)adaptation: micro- and mesocircuit plasticity in early adversity and trauma (Stefan Remy)

JE2: Investigation of neuroimaging-derived predictors and mediators of disease trajectory in affective disorders (Ronny Redlich)

JE3: Modification of inappropriate social interaction and synchronization patterns (Ilona Croy)

JE4: Developmental aspects and therapy of neuroimmunological mechanisms in depressive disorders and post-inflammatory sequelae (Christian Geis)

JE5: Investigation and modulation of the interplay between body and psyche in people with obesity (Nils Opel)

JE6: Early life pathways of neuronal access points for neuromodulation in adolescence (Kerstin Krauel)

JE7: Early detection and success enhancement of psychotherapy using pharmacological and digital augmentation (Martin Walter, Florian Junne)

MA1: Cohort-based approach for mechanism-oriented identification of risk and protective factors and population-based prevention (Heike Tost)

MA2: Signatures and models of risk and protective mechanisms across the lifespan: characterization and implementation of digital twins (DMT) for personalized interventions (Emanuel Schwarz)

MA3: Transfer of neuronal mechanisms to the psychotherapeutic treatment of ACE-related social dysfunction in adolescents with SMI (Valery Grinevich)

MA4: Mechanism-based modular interventions for traumatized adolescents and young adults: development, allocation, digital outcome prediction and monitoring (Sabine Herpertz)

MA5: Interactions in small groups in lively environments: Focus on fostering group cohesion in work and study environments (Harald Gündel)

MA6: Mental health, dissemination; dissemination and implementation research (Jörg Fegert)

MUC 1: Investigation of the significance of early traumatic experiences for the development, phenotype and course of mental illnesses and development of new individualized and disorder-specific interventions (Thomas Ehring)

MUC 2: Characterization of neuroimmunological processes at the transition between health and mental disorder across the lifespan (Josef Priller)

MUC 3: Development of population-based, biopsychosocial etiology and risk models based on multidimensional, individual trajectory data (Nikolaos Koutsouleris)

MUC 4: Development of stepped care models for the initiation and scheduling of therapies (Jochen Gensichen, Stefan Leucht, Alkomiet Hasan)

MUC 5: Investigation of pregnancy and birth cohorts and the establishment of model systems to study the impact of prenatal risk factors on brain development, physiology, and behavior (Elisabeth Binder, Silvia Cappello)

MUC 6: Investigation of long-term courses of treatment with non-invasive brain stimulation with treatment start in adolescence and young adulthood (Frank Padberg)

MUC 7: Establishment of evidence-based psychiatry and development of a long-term project to reduce stigma and social exclusion in mental illness (Stefan Leucht, Irene Bighelli)

TÜ1: Further development of neuromodulatory treatment approaches from the laboratory to clinical application (Christian Plewnia, Birgit Derntl, Nils Kroemer, Alireza Gharabaghi, Beatrix Barth, Ann-Christine Ehlis)

TÜ2: Improved psychotherapy formats for mechanism-based interventions (Enhanced Psychotherapy) (Katrin Giel, Christian Plewnia, Simone Behrens, Katrin Giel, Johanna Löchner, Tobias Renner, Philipp Schröder, Jennifer Svaldi)

TÜ3: Development of a diagnostic platform through the integration of theory- and data-based computational psychiatry (Peter Dayan, Tobias Kaufmann)

TÜ4: Transgenerational and intergenerational mental health (Johanna Löchner, Tobias Renner, Annette Conzelmann)

TÜ5: Physical-mental interaction of mental and somatic health across the lifespan (Andreas Stengel, Stephan Zipfel)

TÜ6: E-health-supported longitudinal assessment of mental and somatic abnormalities, risk and resilience factors of preterm infants and individualized, interdisciplinary, and multimodal stepped care (Annette Conzelmann, Tobias Renner)